It’s down to the final eight in the Champions League as European footballing heavyweights battle to be crowned champions of Europe.
The two Manchester sides have a whole lot of work to do in the second legs as they try to overturn deficits.
City appears to have a much easier job returning home with just a one goal deficit and United have to try and get themselves back from 2-0 in Barcelona.
Elsewhere the Ajax has another massive test going to Turin to try and pull off another massive upsets.
Read on for our previews and predictions for every Champions League Quarter Final match.
Liverpool Vs Porto
Wednesday 10 April, 5:00am, Anfield
Even the most hardened neutral would have to admit these European nights at Anfield bring something special to the competition.
Porto gets a chance to spoil that party and pick up their first ever win over the Reds.
They have visited Anfield on three occasions losing a UEFA Cup knockout tie 2-0 in 2001, a Champions League group stage match 4-1 in 2007 but did manage a 0-0 draw in last year’s knockout stages.
That didn’t help too much having lost the first leg 5-0 and if the Reds turn up to play, another 5-0 win could be on the cards.
With a Premier League title race to focus on as well, you get the feeling Liverpool will want to kill off the tie in the first leg with a big win.
Back Liverpool to Win & Over 3.5 Goals @ $3.00
Tottenham Vs Manchester City
Wednesday 10 April, 5:00am, Tottenham Stadium
It’s the first of three straight clashes between Tottenham and Manchester City across the Premier League and Champions League and a European debut for Spurs’ new stadium.
With the defending Premier League champions coming to visit though, it might not be as happy as its opening night against Crystal Palace.
City has won the last three meetings between these sides but only managed a 1-0 win at Wembley in October.
This has every chance of being an even match but it’s rare to get City at this price so why not jump on one of the best teams of this era.
Back Manchester City to Win @ $1.75
Ajax Vs Juventus
Thursday 11 April, 5:00am, Johan Cruijff Arena
Do you back the player or the team?
Ajax’s run to the quarter finals has been nothing short of remarkable and if Juventus takes the plucky underdog lightly, they could be in for a real battle here.
Juventus has received a massive boost with the news Cristiano Ronaldo will be fit to take part in this game after injuring himself on international duty last month.
If you were ranking these sides player for player, Juventus would have the edge pretty much all over the park and with the difference maker Ronaldo in the mix, you have to back the visitors to come away with a win in the first leg.
It might not come easy though as Ajax have shown they are not afraid to have a go at more fancied opponents.
Back Juventus to Win and Both Teams to Score @ $4.40
Manchester United Vs Barcelona
Thursday 11 April, 5:00am, Old Trafford
Since United’s miraculous comeback in Paris, they have been knocked out of the FA Cup and dropped out of the Premier League’s top four, so the Champions League is their only remaining chance for silverware and might be their only way back into the competition next year.
In the Champions League era, United has only beaten Barcelona once in eight meetings and that was in the second leg of a knockout tie on the way to their triumph in Moscow.
To have any chance of advancing to the semi finals, United needs a positive result here at Old Trafford to take something to Barcelona but that is a massive ask against a team like Barcelona.
The Catalan giants have not lost in their last five and scored 18 goals in that time, half of which came from Lionel Messi.
Ole Gunnar Solskjaer knows that the Argentinian maestro will have an impact on this game, he just has to find a way to minimise it.
Perhaps United’s best approach would be to try and score a few goals to go carry into second leg but I just can’t see them winning this game so I’ll back a score draw.
Back Both Teams to Score and a Draw @ $4.33
Barcelona Vs Manchester United
Wednesday 17 April, 5:00am, Nou Camp
FIRST LEG: Barcelona Won 1-0
If you’re a United fan looking for a glimmer of hope, the side could be in a worse position than having to chase down a 1-0 deficit at the Nou Camp.
Even so it’s a massive ask to try and beat a Barcelona side that just doesn’t lose at home.
In the league and cup competitions so far this year, they have lost just once in front of their fans and a draw here would be enough to send them through.
These are the sorts of games that seem to bring out the best in Messi and after three straight quarter final exits, he will stand tall here.
Back Lionel Messi to Score 2 or More Goals and Barcelona to Win (SGM)
Juventus Vs Ajax
Wednesday 17 April, 5:00am, Allianz Stadium
FIRST LEG: 1-1 Draw
A lot of the same sentiments from Barcelona can carry over to Cristiano Ronaldo and Juventus here, except the Turin club is chasing its first Champions League title since 1996.
They brought the Portuguese superstar over from Madrid to help them end that drought after losing five finals in that time and he will need to be at his best to get them over the line here.
We all saw just what Ronaldo is capable of in the last round of the competition scoring a hat-trick to eliminate Atletico Madrid.
As impressive as Ajax’s run has been, it should come to an end here as one of the best in the world makes his mark on what has been his competition.
Back Cristiano Ronaldo to Score and Juventus to Win @ $4.00
Manchester City Vs Tottenham
Thursday 18 April, 5:00am, Etihad Stadium
FIRST LEG: Tottenham Won 1-0
Part two of the City-Tottenham trilogy sees these sides face off 64.5 hours before doing it again in the Premier League.
Tottenham’s job got a lot more difficult in the second half of their home leg losing captain Harry Kane to an ankle injury, although his absence didn’t trouble them too much at Huddersfield.
Working in their favour is the fact a draw is good enough to get them home in the game but it will be a massive task to shut out City’s attacking line.
It’s unlikely that this will be another one goal slugfest which does make extra time and penalties highly unlikely.
To go through in 90 minutes, City needs to win this leg by two clear goals but they have the talent to do so and at that price, are worth backing as a handicap play.
Back City to Win -1 Goal @ $1.83
Porto Vs Liverpool
Thursday 18 April, 5:00am, Estadio do Dragao
FIRST LEG: Liverpool Won 2-0
The Reds are in the box seat here after a two goal win at home and Mo Salah looking like his old self against Chelsea on the weekend.
Last season you might have given Porto a chance to mount a comeback but the Reds have been much more defensively resilient in this season.
They gave up one goal to Bayern Munich in the Round of 16 and haven’t conceded three goals in a game since a win against Crystal Palace on January 19 and that was the only time they have let in three all season.
Bottom line, Liverpool are too good to lose this game by three or more and should progress, but Jurgen Klopp may opt to try and kill off this tie early on, so expect a few goals here.
Back Over 2.5 Goals @ $1.87