And so begins the season of double duty for a handful of Premier League clubs with European commitments bringing about squad rotation, prioritising and much more.
Manchester United, Manchester City, Tottenham and Liverpool all have the Champions League to battle with, while Chelsea and Arsenal fans can prepare for a lot of late Sunday nights with the Europa League dictating their schedule.
Clubs like Watford and Bournemouth, who only have the domestic front to compete on, will want to take advantage of their rivals’ split focus and build on their promising start.
It is another big weekend of action and our complete EPL Week 6 tips can be found below.
Fulham Vs Watford
Saturday 22 September, 9:30pm, Craven Cottage
Watford’s bubble burst at the weekend and their loss to Manchester United ended their perfect start to the campaign.
They have a chance to bounce back against a Fulham side that has just one win this season so far and are giving up an average of over two goals per game.
For all of their struggles getting wins, goals have been flowing when Fulham take the field and they have 17 total goals from their last four matches.
This has the makings of another high scoring affair and the visitors should be able to claim the spoils of victory here.
Back Watford to Win and Both Teams to Score @ $4.80
SGM: Watford to Win, Over 2.5 Goals, Roberto Pereyra Anytime Goalscorer
Burnley Vs Bournemouth
Sunday 23 September, 12:00am, Turf Moor
With the way their season has started off, Burnley will be glad they have had a full week to prepare for this game without the distraction of the Europa League.
Sitting dead last and in desperate need of a win, they take on a Bournemouth side sitting in 5th place, probably where Burnley expected themselves to be at this stage.
They were able to cover up the lack of goals in the squad last season, however they are conceding at a much higher rate and that makes things considerably tougher for a side that isn’t filled with noted goal-scorers.
Having failed to score in their last two games, they appear to be in for another long afternoon and Bournemouth offer excellent value at this price.
Back Bournemouth to Win @ $2.50
SGM: Bournemouth to Win, Jermain Defoe First Goalscorer, Burnley Under 1.5 Goals
Cardiff Vs Manchester City
Sunday 23 September, 12:00am, Cardiff City Stadium
The winless hosting the… loss-less… defeat-less… whatever, this is a game between a side that will be battling for Premier League survival and a side battling for the Premier League title (again).
This has never been a friendly fixture for Cardiff, they have a poor record against City with 21 losses and 20 draws from the 50 meetings.
City have won the last two meetings and will be looking for their first three game winning streak against Cardiff ever.
While they were held to a draw by Wolves in their last away match it is hard to see Cardiff really challenging City without some sort of divine intervention here.
Back Manchester City to Win -2 Goals @ $2.15
SGM: Manchester City to Win, Leroy Sane First Goalscorer
Crystal Palace Vs Newcastle
Sunday 23 September, 12:00am, Selhurst Park
It is just over a month into the season, but things are already getting a bit restless at St James’ Park with Newcastle struggling to live up to their preseason expectations with just one point so far.
Crystal Palace picked up their first win since opening day with a victory over Huddersfield and they will want to take advantage of another struggling opponent here.
They will need to reverse a poor history against Newcastle however with just one victory in 14 meetings since 2000.
While Crystal Palace are looking like the better side of late, Newcastle did pick up a draw in this fixture last season and if they can score first they should find a way to get something from this.
Back the Draw @ $3.25
SGM: Over 2.5 Goals, Christian Benteke Anytime Goalscorer, Joselu Anytime Goalscorer
Leicester City Vs Huddersfield Town
Sunday 23 September, 12:00am, King Power Stadium
Leicester have a good chance to end their two-match losing streak here with a home game against struggling Huddersfield.
In the same match last year Leicester ran out 3-0 winners and all of their goals came in the second half.
This may be the week that Huddersfield can add to their goals tally with an already vulnerable Leicester defence about to be even more short staffed thanks to captain Wes Morgan’s suspension.
Even without their captain Leicester should have the quality to win this match at home.
Back Leicester to Win and Both Teams to Score @ $4.00
SGM: Leicester to Win, Jamie Vardy First Goalscorer, Over 1.5 Leicester Goals
Liverpool Vs Southampton
Sunday 23 September, 12:00am, Anfield
Confidence on Merseyside is at an all time high – at least for Liverpool supporters!
Fresh off a win over PSG in the Champions League and five straight Premier League victories, they face a Southampton side they took six points against last year while holding them goalless.
That stingy defence that has conceded a league low two goals this season will be tested here with Southampton scoring two goals in each of their last two matches.
Of the six goals Southampton have scored this season, five have come in the second half by which stage Liverpool could be home free if they get off to a fast start.
Back Liverpool to Win to Nil @ $1.91
SGM: Liverpool Win to Nil, Saido Mane First Goalscorer, Over 2.5 Liverpool Goals
Manchester United Vs Wolverhampton
Sunday 23 September, 12:00am, Old Trafford
The mind games between Wolves and Manchester United have already begun, despite the home side heading into this game as heavy favourites.
As much fun as the early season drama was at United (for outsiders at least) the last two games have seen a return to form with back to back wins.
Wolves have won back to back games 1-0 and will take plenty of confidence into this match, which will be the first time these sides have met since March 2012.
In the 2011-2012 season, United won both games by an aggregate score of 9-1 however this one should be a bit closer.
Back Manchester United to Win and Under 3.5 Goals @ $2.30
SGM: Manchester United to Win, Romelu Lukaku First Goalscorer, Juan Mata Anytime Goalscorer
Brighton And Hove Albion Vs Tottenham
Sunday 23 September, 2:30am, Amex Stadium
Tottenham will be very eager to get back to business and move past their capitulation in the Champions League against Inter Milan at the San Siro.
Last season they were held to a draw at this venue, but start as favourites for this one and actually offer decent value even if the squad does get rotated a bit.
Despite being on a three match losing streak in all competition, it is too hard to pass up Tottenham at these odds, although it would not be a surprise if Brighton score first.
Back Tottenham to Win and Both Teams to Score @ $3.40
SGM: Tottenham to Win, Lucas Moura to Score 2 Goals or More
West Ham Vs Chelsea
Sunday 23 September, 10:30pm, London Stadium
In the midst of their struggles under Antonio Conte last season, Chelsea picked up just one point from their meetings with West Ham.
Things have changed just a bit since then with Chelsea flying under new management and Eden Hazard off to a superb start.
West Ham finally picked up their first win of the season last week after four straight losses and started to look like the side many expected them to at the start of the year.
They have a decent record against Chelsea since their most recent promotion, taking advantage of vulnerable opposition but at the moment this is far from a vulnerable side.
Chelsea, even on short rest after the Europa League, will still be able to hold off West Ham here.
Back Chelsea to Win Both Halves @ $3.75
SGM: Chelsea to Win, Eden Hazard First Goalscorer, Over 2.5 Goals
Arsenal Vs Everton
Monday 24 September, 1:00am, Emirates Stadium
Outside of a solitary in win December 2016, recent history in this fixture has been all Arsenal with the home side favoured to extend their run to four straight wins and eight of the last nine.
The Gunners put up five goals in both meetings last season and while a repeat of that showing is an admirable target, it would be a bit too much to expect.
Even with the short turnaround after the Europa League, Arsenal are likely to field a close to full strength side here so it is not worth making too many adjustments over that.
What is worth staying away from for now is the goalscorer market for the Gunners with 10 different goalscorers contributing all 10 goals.
They are still yet to keep a clean sheet in the league this season so do not be at all shocked if Everton get a goal or two here as well.
Back Arsenal to Win and Both Teams to Score @ $2.70
SGM: Arsenal to Win, Theo Walcott Anytime Goalscorer, Over 2.5 Goals
It’s time for the EPL Week 6 picks are we are starting to learn the identities of these teams.
If you’re not a Manchester fan, things are looking more than a bit scary as the red and blue halves seem to be in a contest for who can have the biggest win.
Arsenal on the other hand will just be happy they didn’t get smacked around Stamford Bridge for once as they showed a bit of resiliency to match Chelsea and hold out for a draw.
With the midweek League Cup action over and done with (it was enthralling wasn’t it?), it’s back to the big games for the big boys of English football.
West Ham United Vs Tottenham Hotspur
Saturday 23 September, 9:30pm, Olympic Stadium
Tottenham will be eager to leave Wembley where they have struggled in the league and head across London to face rivals West Ham at the Olympic Stadium.
Despite the contrasting fortunes of the two sides, recent fixtures between the sides have been relatively evenly split with both sides claiming victory in their last two home games.
This year West Ham started slow but have been able to arrest their slide with a win and a draw against Huddersfield and West Brom.
Even then it is hard to look past Spurs and if they are serious title contenders (which they continue to claim to be), they should be able to win this game by two or more goals.
Back Tottenham to Win -1 at $2.63
Burnley Vs Huddersfield Town
Sunday 24 September, 12:00am, Turf Moor
Huddersfield do not like to give up goals and Aussie midfielder Aaron Mooy is involved with a lot of the dirty work, currently sitting second in the Premier League with nineteen tackles made behind Leicester midfielder Wilfred Ndidi and ahead of Ngolo Kante
Burnley managed to get a shock draw at Anfield last week and are getting by playing tight, competitive matches.
Kiwi striker Chris Wood is in fine form scoring in two of his last three games and I fancy his chances of getting through the stingy Huddersfield defence.
Back Chris Wood as an Anytime Goalscorer at $2.63
Everton Vs Bournemouth
Sunday 24 September, 12:00am, Goodison Park
The Toffees are off to a very slow start and the pressure is ramping up on manager Roberto Martinez to find the answers.
Bournemouth will be experiencing a slight confidence boost having beaten Brighton last weekend but they are also trying to get into a mid-table fight rather than a relegation battle.
Neither side have been overly proficient and the return of Wayne Rooney is yet to fill the void left by Romelu Lukaku.
Take this game as a low scoring encounter that Everton might just find a way to get by in.
Back Everton to win and Under 2.5 Goals at $4
Manchester City Vs Crystal Palace
Sunday 24 September, 12:00am, Etihad Stadium
City are the high flying side in the league right now and look borderline unstoppable, running riot over all comers so far.
Having hit Watford for six goals last weekend, the strike pairing of Gabriel Jesus and Sergio Aguero look like they are playing FIFA on Semi-Pro difficulty at best right now.
Which of course means that they will hit some sort of unexpected speed bump soon which will halt all of their momentum.
It’s hard to see Palace providing that speed bump as they are yet to score a goal this season and sit rooted to the bottom of the table.
For me, this game is a case of City will win but by how many, a midweek game coming up against Shakhtar might mean we get some squad rotation but they are still a class above Palace.
Back City to Win -2 Goals at $2.05
Southampton Vs Manchester United
Sunday 24 September, 12:00am, Selhurst Park
Historically this is a fixture that United have dominated but in recent times, the Saints have been able to spring a handful of upsets.
During last season’s trip to St Mary’s, United were left frustrated with a 0-0 midweek draw but their start to this season suggest that won’t happen again.
Romelu Lukaku scored five times in eight appearances against Southampton adding another three assists during his time with Everton so he loves playing them.
For the Saints, they are not as free flowing but are still finding ways to grind out results, winning twice and drawing twice so far this year.
United might find themselves in a similar situation to last week against Everton where they battle through a game before adding to the margin in the final 10 minutes.
Back Lukaku to Score & United to Win at $2.80
Stoke City Vs Chelsea
Sunday 24 September, 12:00am, Britannia Stadium
The Premier League’s road warriors in Chelsea travel to the infamous home ground of Stoke looking to extend their run of seven of eight victories away from home.
They will be forced to do it without David Luiz however as he became the latest player to pick up a red card.
It is not the home ground of old for Stoke as they now play a much more traditional style of football, which has helped the likes of Xherdan Shaqiri and Eric Maxim Choupo-Moting combining for nine goalscoring opportunities so far.
They haven’t scored as many of those as they would have liked however but they haven’t been kept off the scoresheet since the opening day.
With that in mind, I think Chelsea should get by here but Stoke will be able to do what Arsenal couldn’t and score a goal.
Back Chelsea to Win and Both Teams to Score at $3.60
Swansea City Vs Watford
Sunday 24 September, 12:00am, Liberty Stadium
Watford will be reeling after their trouncing at the hands of Manchester City, however they would like to think they are not as bad as that scoreline might suggest.
Swansea on the other hand produced a fantastic rearguard action to hold off Tottenham and increase their Wembley woes.
It might only take one goal to win this game and Swansea have the players up front to create the chances that will make the difference.
Back Swansea to Win at $2.35
Leicester City Vs Liverpool
Sunday 24 September, 2:30am, King Power Stadium
It will be a proper sense of déjà vu as these sides face off for the second time in less than a week.
Leicester have the bragging rights claiming a 2-1 victory in the Carabao Cup and have also won the last two league meetings at the King Power Stadium.
Something has seemingly gone off the boil with Liverpool at the moment as they struggle to find a clear playing style.
I like Leicester to pull off the upset of the weekend and heap more misery on Liverpool.
Back Leicester to Win at $3.90
Brighton And Hove Albion Vs Newcastle United
Monday 25 September, 1:00am, Amex Stadium
Brighton have taken a cautious approach to their maiden Premier League voyage, ensuring that they avoid conceding too many goals.
It has come at the expense of attacking flair however, in last week’s win over West Brom, they recorded just three touches inside the opposing box.
This weekend they face fellow promoted side but still Premier League veterans in Newcastle, who were the only side to beat them both home and away in the Championship last season.
Where Brighton are struggling to score goals, Newcastle are equally tight at the back and have only let in four goals so far.
There is not a lot of value on offer here and I would suggest sitting back and enjoying whatever this game might throw at us.
Arsenal Vs West Bromwich Albion
Tuesday 26 September, 5:00am, Emirates Stadium
The matchweek closes out with Arsenal facing West Brom at the Emirates in a Monday Night Fixture that on paper looks relatively routine.
With players such as Lacazette, Ozil and Sanchez up front the Gunners should be able to fire themselves past West Brom.
Last time they played however, West Brom managed to surprise Arsenal and win 3-1 and are looking for their first successive league wins over them since 1977.
It will be no easy task however as they have not won at the Emirates since 2010 and Arsenal will not want to fall off any further in the top four race.
Arsenal should win but there is not really any value in taking them head to head and at the moment, with the squad still looking somewhat shaky, there is no certainty about whether or not they could cover any clear margin so this game looks like a stay away for the time being.
Week 6 of the 2016/2017 season begins with an deadset blockbuster between Manchester United and Leicester City, but this is far from the only big game of the weekend.
London rivals Arsenal and Chelsea will do battle for the first time this season at Emirates Stadium and this is another game that could have crucial consequences for the championship race.
This is another excellent weekend of English Premier League betting and you can find our thoughts and betting predictions for every game below.
Manchester United Vs Leicester City
Saturday 24 September, 9:30pm, Old Trafford
The Jose Mourinho era at Manchester United has got off to a very shakey start and they face another tough assignment against Leicester City this weekend.
Manchester United were credible in defeat against Manchester City, but they have since produced a pair of very poor performances against Feyenoord and Watford.
The Red Devils will still go into this clash as clear favourites and they have been a losing betting proposition as home favourites over the past 12 months.
In complete contrast, Leicester City have thrived in the past week.
They made their European debut with a dominant victory over Club Brugge and they did the job professionally against Burnley in the English Premier League.
It is no surprise that Leicester City have been one of the best betting teams in the English Premier League over the past 12 months and they have won five of their past 11 games as away underdogs for a huge profit.
It is ridiculous that Leicester City are as long as $5.25 to win this clash and they are easily the best value betting play of the weekend.
Back Leicester City To Win @ $5.25
Bournemouth Vs Everton
Sunday 25 September, 12:00am, Goldsands Stadium
Everton have made a stunning start to the English Premier League season and they are clear favourites to make it five wins on the trot.
Everton drew with Tottenham in their opening game of the season, but they have since beaten West Bromwich Albion, Stoke City, Sunderland and Middlesbrough to sit in second position on the table.
They have won six of their past eight games as away favourites for a sizeable profit and they look very well-placed to continue their winning run in this fixture.
Bournemouth were no match for Manchester City at Etihad Stadium last weekend and they face another tough assignment in the early hours of Sunday morning.
The Cherries have won just two of their past seven games as home underdogs for a loss and they are a particularly poor 2-6-9 on the back of a loss.
Everton look like a particularly safe bet to win in the English Premier League this season and anything better than even money is a great bet.
Liverpool Vs Hull City
Sunday 25 September, 12:00am, Anfield
Liverpool produced another impressive performance to upstage Hull City last Saturday morning and they are extremely short-priced favourites to beat Hull City this weekend.
Liverpool have made a very promising start to the season, but they are still a tough side to trust at Anfield and they are 7-7-2 in their past 16 games as home favourites.
Hull City have only now got what could be considered anything like a proper sized English Premier League squad and it is fair to say that they have overachieved to start the season.
The Tigers have taken four points from their two games as away underdogs this season, but it really is tough to back them in this fixture.
Liverpool really should win this game comfortably, but there is no value at their current price and I am happy to stay out from a betting perspective.
Middlesbrough Vs Tottenham
Sunday 25 September, 12:00am, Riverside Stadium
Middlesbrough have suffered back-to-back defeats following their promising start to the season and they face another tough task against Tottenham this weekend.
Middlesbrough are yet to win a game at home this season and their performance against Crystal Palace a fortnight ago was particularly poor for a side that is capable of playing some good football.
Tottenham are still yet to lose a game this season following their narrow win over Sunderland and they will start this game as clear favourites.
This has been a position that they have thrived in over the past 12 months – they have won seven of their past 11 games as away favourites for a healthy profit.
Tottenham really look to be finding their groove this season and they are another favourite that represents value at their current price of $1.95
Back Tottenham To Win @ $1.95
Stoke City Vs West Bromwich Albion
Sunday 25 September, 12:00am, Britannia Stadium
This is a crucial game for Stoke City who have taken just a single point from their five games to date this season.
Stoke City were handled heavy defeats at the hands of both Tottenham and Crystal Palace in the past fortnight and it will be a surprise to some that they are set to start this clash as such clear favourites.
In saying that, Stoke City have won four of their past eight games as home favourites for a narrow profit and they generally perform close to their best at Britannia Stadium.
West Bromwich Albion upset West Ham to record a crucial win last weekend and they will take plenty of confidence into this clash.
They have won just three of their past 18 games as away underdogs, but they have taken at least a point from ten of their games and they have a strong record against Stoke City.
Both these teams can be hard to trust from a betting perspective and I am more than happy to stay out of this fixture.
Sunderland Vs Crystal Palace
Sunday 25 September, 12:00am, Stadium Of Light
Crystal Palace have found form in recent weeks and they will start this clash as favourites to make it three wins on the trot.
Crystal Palace clearly took plenty of confidence from their win over Middlesbrough and they produced one of their best performances in the past 12 months against Stoke City.
Away favourtism is a position that Crystal Palace have not had much experience in in the past 12 months and they have lost their past two games in this scenario, while they are 3-3-3 on the back of a win.
Sunderland have started the English Premier League season in truly putrid fashion and they have taken just the one point from their five games to dates.
They have won just three of their past 12 games as away underdogs and at this stage of the season it is very tough to see how they won’t end up in the relegation battle.
Sunderland have really struggled to score this season and the $2.88 available for Crystal Palace to keep a clean sheet looks like outstanding value.
Back Crystal Palace To Keep A Clean Sheet @ $2.88
Swansea City Vs Manchester City
Sunday 25 September, 12:00am, Liberty Stadium
The Pep Guardiola era could not have got off to a better start.
The master manager has Manchester City playing a simply outstanding brand of football and they have already solidified their position as dominant title favourites.
Manchester City will start this clash with Swansea City as dominant favourites and it would take a braver man to me to suggest that they won’t be able to secure the three points – even if they have only won four of their past 13 games as away favourites.
Swansea City have struggled since their opening day victory against Burnley and their tough draw to start the season does not get any easier.
Liberty Stadium has been far from a fortress for Swansea City in the past 12 months and they have won just two of their past six games as home underdogs.
There is no value at the current price on offer for a Manchester City victory, but they really should be able to maintain their unbeaten start to the season.
Arsenal Vs Chelsea
Sunday 25 September, 2:30am, Emirates Stadium
This is easily the best game of the weekend and will be a true test of where both these teams sit at this stage of the season.
Arsenal made it three wins on the trot with a dominant performance against Chelsea and the Gunners will go into this clash as clear favourites – despite the fact that they have lost six of their past eight games against their rivals.
Arsene Wenger’s men have proven to be a safe betting play as home favourites in the past 12 months – winning 12 of their past 17 games in this scenario – and they are 11-5-3 on the back of a win across the same period.
Chelsea are another side that has hit a roadblock in the past fortnight – dropping points against Swansea City before losing to Liverpool.
New manager Antonio Conte still has plenty of work to do with this side and their poor record of 1-3 as away underdogs does not encourage confidence.
If Arsenal are genuine title contenders they really should be able to win this clash and I am keen to back them to do just that.
Back Arsenal To Win @ $2.38
West Ham United Vs Southampton
Monday 26 September, 1:00am, Olympic Stadium
The market suggests that there will be very little between West Ham and Southampton in this clash.
It has been far from a positive start to the season for West Ham and they go into this clash on the back of two very poor performances against Watford and West Bromwich Albion.
They will go into this clash as narrow favourites and this is a position in which they have thrived in the past 12 months – they have won five of their past seven games as home underdogs for a big profit.
Southampton have also made a sluggish start to the season, but they returned to winning form with a narrow victory over Swansea City last weekend.
The Saints have won three of their past seven games as away favourites for a narrow loss and their recent record against West Ham is not particularly strong.
I am willing to give West Ham United another chance this weekend, but there will be serious warning signs if they put in another lacklustre performance.
Back West Ham To Win @ $2.90
Burnley Vs Watford
Tuesday 27 September, 5:00am, Turf Moor
This is another clash in which the market is struggling to split the two sides.
Watford produced their best performance of the season to date to beat Manchester United this weekend and they have been impressive in their wins over both West Ham and and the Red Devils.
Despite those victories they will still only go into this clash as narrow favourites and they proven to be a winning proposition in the past 12 months as the punter’s elect.
Burnley were no match for Leicester City this weekend and they have proven to be a tricky side to analyse so far this season.
It will be interesting to see what approach they take into this clash – they were highly conservative against both Liverpool and Leicester – but Sean Dyche could elect to be a touch more positive against one of the weaker sides in the competition.
I have been impressed by the quality of football that Watford have played in the past fortnight and I am confident they can make it three wins on the trot against Burnley.
Back Watford To Win @ $2.60