Houston Texans host Buffalo Bills in Week 1 of the 2026 NFL season at NRG Stadium on Monday. Read on for our full match preview, betting tips, and best odds.
Josh Allen gets his revenge game after the Texans beat Buffalo twice last season, including an eight-sack, 2 INT demolition. New Bills head coach Joe Brady takes over, walking into a matchup against Houston’s genuinely elite defense, while C.J. Stroud needs a bounce-back year with contract pressure building.
D.J. Moore gives Allen a proper veteran target but I’m expecting a run-first affair for both sides with plenty of volume for Cook and Montgomery. Houston’s defense is the scarier unit here, but I’m backing Allen’s ceiling over Stroud’s in a shootout-adjacent, mistake-filled game.
Houston Texans vs Buffalo Bills Odds & Popular Betting Markets
Here’s a quick look at the current odds and popular betting markets for the Houston Texans vs Buffalo Bills matchup.
*odds are correct at the time of publishing and are subject to change