The Eagles host the Panthers at Lincoln Financial Field in Week 6, with kick-off at 4:00am AEDT on Monday 19 October. Here's our Eagles vs Panthers prediction, along with the best odds at Ladbrokes. Jalen Hurts is actually ruled out with a blood clot issue in his calf, handing the keys to Tanner McKee, and as a Cowboys fan, loving this demise of the Eagles, and expecting it to continue. Philadelphia have lost three straight, and Bryce Young was leading the NFL in passing yards heading into the bye, with Carolina ranked second in passing yards per game and third…

Looking for our Colts vs Titans prediction? The Colts host the Titans at Lucas Oil Stadium on Monday 19 October, with kick-off at 4:00am AEDT, and our best bet is ready. The curious case of Cam Ward continues. Tennessee are still pushing forward with the young quarterback despite a season that's been hard to find a positive in, just a 63.2% completion rate, a 3 to 3 touchdown to interception ratio and only 5.8 yards per attempt, 23rd in the league in adjusted QBR. It's damning for Titans fans, but this team is bad, and they're going to be bad…

It's Giants vs Saints at MetLife Stadium in Week 6, kicking off at 4:00am AEDT on Monday 19 October. Below is our prediction and the best odds at Ladbrokes. If we're giving credit to Geno, we have to give credit to the undefeated Jameis Winston too, everyone's favourite quarterback that nobody wants running their team, and he is playing pretty unreal. Back to back three touchdown games, even if one came in an overtime tie the Giants would be thrilled to have escaped with. The Jameis Express continues against a Saints team that has been seriously underperforming, getting embarrassed by…

The Falcons take on the Bears at Mercedes-Benz Stadium on Monday 19 October, with kick-off at 4:00am AEDT. Find our Falcons vs Bears prediction and the Ladbrokes odds we like below. Feels like we're being robbed of a genuine heavyweight matchup here with both quarterback situations up in the air. Michael Penix Jr. looks more likely to miss out with that rib injury, even if Atlanta are playing coy about it, while Caleb Williams is still working his way back from the hamstring injury that's sidelined him for weeks, not helped by all the noise about him supposedly overselling it.…

Kick-off for Browns vs Ravens is 4:00am AEDT on Monday 19 October at Huntington Bank Field. Below is our Week 6 prediction and the markets we like at Ladbrokes. It's going to be the Derrick Henry show again. Tyler Huntley did a good job filling in for an injured Lamar Jackson last week, and Jackson's got a real chance to return here, which only strengthens the case for Baltimore. Cleveland has been a surprise packet the last few weeks and could retake sole possession of the AFC North with a win, which is a wild thing to even type, but…

The Buccaneers and the Steelers meet at Raymond James Stadium on Monday 19 October, with kick-off at 4:00am AEDT. We've weighed up both sides to land on our Buccaneers vs Steelers prediction and best bet. Dallas made undrafted rookie Jalon Daniels look like Brady and Bucky Irving look like Bo Jackson last week, 241 rushing yards for Tampa Bay, 165 of those from Irving, and Daniels a clean 19 of 25 for 189 yards and a touchdown with no turnovers in his first career win. That almost certainly says more about how bad Dallas's defense was than it does about…

The Patriots face the Jets at Gillette Stadium on Monday 19 October from 4:00am AEDT. Here's our Patriots vs Jets prediction along with the best odds for the game. A quiet appreciation first for Geno Smith, who is having a genuinely good season. Up until last week his turnovers were minimal, and his touchdown to interception numbers are up there with the best in the league, 69.4% completion, 1,084 yards, six touchdowns and zero picks through five games, his 147 attempts without an interception the third most in football behind only Jared Goff and C.J. Stroud. This is going to…

Jaguars vs Texans kicks off at 12:30am AEDT on Sunday night (Monday 19 October) at Wembley Stadium in London. Here's our Week 6 prediction, plus the best odds at Ladbrokes. Houston's defense has been underperforming all season, but the offense is starting to fire a little, an interesting turnaround after their first win of the year, a dominant one over Tennessee. Jacksonville got a huge get out of jail free card last week, surviving a tight one in London and losing starting left tackle Anton Harrison to injured reserve in the process. Division rivals tend to play a lot tighter…

New Orleans Saints host Atlanta Falcons in Week 4 of the 2026 NFL season at Caesars Superdome on Tuesday. Read on for our full match preview, betting tips, and best odds. Can lightning strike twice? Penix was crazy good after an early INT, snapping Green Bay's 13-game home-opener winning streak with a 256-yard performance, while Bijan Robinson ran for 194 yards and two touchdowns in that win. Tyler Shough has been just as hot for New Orleans, throwing a career-high four touchdowns against the Raiders last week and sitting on over 900 yards and eight scores on the season -…