Buffalo Bills host Los Angeles Chargers in Week 3 of the 2026 NFL season at Highmark Stadium on Monday, 28th September. Read on for our full match preview, betting tips, and best odds.
FUN FACT: The Chargers are 0-2, the first team in history to start a season that way against two opponents who each lost 14 or more games last year.
Which tells you everything about how bad this start has been. Justin Herbert is completing under 60 percent of his passes, has thrown more interceptions than touchdowns, and has taken six sacks already.
Meanwhile Josh Allen is playing MVP-calibre football in Buffalo, already up to nine total touchdowns through two games.
There’s next to no faith left in this Chargers team, and with a brutal run coming up against the Seahawks, Broncos, Chiefs, Ravens and Rams, the hot seat talk around Jim Harbaugh feels premature but not unreasonable considering this could be a team that doesn’t win until November.
Buffalo Bills vs Los Angeles Chargers Odds & Popular Betting Markets
Here’s a quick look at the current odds and popular betting markets for the Buffalo Bills vs Los Angeles Chargers matchup.
*odds are correct at the time of publishing and are subject to change
| Team | Odds | |
|---|---|---|
| Buffalo Bills (-2.5) | 1.38 | Bet Now |
| Los Angeles Chargers (2.5) | 3.00 | Bet Now |
NFL odds correct as of 24/09/2026 and subject to change. Event scheduled to start at 28/09/2026 3:00am AEST.
NFL odds correct as of 24/09/2026 and subject to change. Event scheduled to start at 28/09/2026 3:00am AEST.