New York Giants vs Arizona Cardinals Prediction, Odds & Best Bets

New York Giants vs Arizona Cardinals Prediction, Odds & Best Bets

New York Giants host Arizona Cardinals in Week 4 of the 2026 NFL season at MetLife Stadium on Monday. Read on for our full match preview, betting tips, and best odds.

New York Giants
vs
Arizona Cardinals
Monday 5 October 2026, 3:00 AM AEST – MetLife Stadium, East Rutherford
Cardinals -2.5; Jeremiah Love ATD; Trey McBride ATD

The Giants at 2-1 is genuinely surprising, though last week’s win over the Titans was a needed gimme given all their injuries. The big news this week is the trade for J.J. McCarthy, but Harbaugh has confirmed Jameis Winston keeps the job for now and despite a couple of rough outings, Winston’s probably still the better option of the two.

Tank Bigsby will do what he does grinding it up the middle, but with the Giants banged up on both sides of the ball, this looks tough against a Cardinals side that’s been overperforming all year.

Jacoby Brissett is playing solid football, and with Trey McBride and the receiving corps clicking, this feels like a big spot for Arizona.

New York Giants vs Arizona Cardinals Odds & Popular Betting Markets

Here’s a quick look at the current odds and popular betting markets for the New York Giants vs Arizona Cardinals matchup.

*odds are correct at the time of publishing and are subject to change 

Other NFL games this week

Washington Commanders
vs
Indianapolis Colts
Sunday 4 October 2026, 11:30 PM AEST – Tottenham Hotspur Stadium, London
Indianapolis Colts -4, Josh Downs To Have 50+ Receiving Yards, Jonathan Taylor 100+ Rushing Yards
Tampa Bay Buccaneers
vs
Greenbay Packers
Monday 5 October 2026, 3:00 AM AEST – Raymond James Stadium, Tampa
Buccaneers +3.5; Christian Watson to score a touchdown.
Philadelphia Eagles
vs
Los Angeles Rams
Monday 5 October 2026, 3:00 AM AEST – Lincoln Financial Field, Philadelphia
Rams (+3.5); Saquon Barkley under 79.5 rushing yards, Nacua ATD
Cincinnati Bengals
vs
Jacksonville Jaguars
Monday 5 October 2026, 3:00 AM AEST – Paycor Stadium, Cincinnati
Ja’Marr Chase ATD; Parker Washington ATD; Bhayshul Tuten ATD
Buffalo Bills
vs
New England Patriots
Monday 5 October 2026, 3:00 AM AEST – Highmark Stadium, Buffalo
Buffalo Bills (-7), Josh Allen 250+ Passing Yards QB Passing Yards, DJ Moore ATD, James Cook 90+ Rushing Yards
Chicago Bears
vs
New York Jets
Monday 5 October 2026, 3:00 AM AEST – Soldier Field, Chicago
Over 43.5 total points, Braelon Allen 50+ rushing yards, Luther Burden 60+ receiving yards.
Baltimore Ravens
vs
Tennessee Titans
Monday 5 October 2026, 3:00 AM AEST – M&T Bank Stadium, Baltimore
Ravens -14, Derrick Henry 100+ rushing yards and a touchdown.
Houston Texans
vs
Dallas Cowboys
Monday 5 October 2026, 3:00 AM AEST – NRG Stadium, Houston
Dak Prescott 2+ Passing touchdowns; Cowboys +3.5
Minnesota Vikings
vs
Miami Dolphins
Monday 5 October 2026, 6:05 AM AEST – U.S. Bank Stadium, Minneapolis
Vikings -11, Jordan Addison ATD, Malik Willis 150+ passing yards.
Seattle Seahawks
vs
Los Angeles Chargers
Monday 5 October 2026, 6:25 AM AEST – Lumen Field, Seattle
Seahawks -7; over 43.5 total points; Jaxon Smith-Njigba ATD; Sam Darnold Over 232.5 Passing yards
Las Vegas Raiders
vs
Kansas City Chiefs
Monday 5 October 2026, 6:05 AM AEST – Allegiant Stadium, Las Vegas
Radiers +4.5, Walker ATD, Jeanty ATD
San Francisco 49ers
vs
Denver Broncos
Monday 5 October 2026, 6:25 AM AEST – Levi’s Stadium, Santa Clara
Broncos +2.5
Carolina Panthers
vs
Detroit Lions
Monday 5 October 2026, 10:20 AM AEST – Bank of America Stadium, Charlotte
Bryce Young 200+ Passing, Jahmyr Gibbs Over 96.5 rushing yards, Amon-Ra St. Brown ATD
New Orleans Saints
vs
Altlanta Falcons
Monday 5 October 2026, 10:20 AM AEST – Bank of America Stadium, Charlotte
Bijan Robinson & Alvin Kamara ATD, Saints H2H