Buffalo Bills host New England Patriots in Week 4 of the 2026 NFL season at Highmark Stadium on Monday. Read on for our full match preview, betting tips, and best odds.
Drake Maye has thrown six interceptions to just one touchdown through three games, an astonishing collapse and the Pats were just torched 35-6 by Jacksonville.
Josh Allen, meanwhile, has been terrific(ish) – five passing touchdowns, six more on the ground, over 780 yards through the air and currently fourth in the league in efficiency. But is coming off a 2 INT game.
There is a sliver of history here, with New England also sitting 1-2 at this point last year before going into Buffalo and upsetting a 4-0 Bills team. Can it happen again? NO.
Despite Allen being a little turnover-happy last week, expect him to right the ship and for Buffalo to put together a big performance that starts to put real distance between them and the rest of the AFC East.
Buffalo Bills vs New England Patriots Odds & Popular Betting Markets
Here’s a quick look at the current odds and popular betting markets for the Buffalo Bills vs New England Patriots matchup.
*odds are correct at the time of publishing and are subject to change
| Team | Odds | |
|---|---|---|
| New England Patriots (7) | 1.88 | Bet Now |
| Buffalo Bills (-7) | 1.92 | Bet Now |
NFL odds correct as of 03/10/2026 and subject to change. Event scheduled to start at 05/10/2026 3:00am AEST.
NFL odds correct as of 03/10/2026 and subject to change. Event scheduled to start at 05/10/2026 3:00am AEST.