RB Leipzig head to the Santiago Bernabéu to face Real Madrid on Thursday 22 October (6:00am AEDT). Read on for our Real Madrid vs RB Leipzig prediction and the best Champions League odds at Ladbrokes.
Real Madrid showed their attacking quality in a dramatic 4-3 victory over Roma, following their opening win against Inter Milan. They’ve already demonstrated that they can find a way through difficult games.
RB Leipzig bounced back from their 4-1 defeat against Como by beating PSV Eindhoven 1-0. That should help their confidence, but travelling to Madrid should make life tough.
Real Madrid is our pick with Champions League tips this week, and they should lead at halftime and fulltime.
Real Madrid vs RB Leipzig Odds & Popular Betting Markets
Here’s a quick look at the current odds and popular betting markets for the Real Madrid vs RB Leipzig matchup.
*odds are correct at the time of publishing and are subject to change
| Team | Odds | |
|---|---|---|
| Real Madrid/Real Madrid | 1.67 | Bet Now |
| Draw/Real Madrid | 4.80 | Bet Now |
| Draw/Draw | 11.00 | Bet Now |
| RB Leipzig/RB Leipzig | 11.00 | Bet Now |
| Real Madrid/Draw | 15.00 | Bet Now |
| RB Leipzig/Real Madrid | 15.00 | Bet Now |
| Draw/RB Leipzig | 17.00 | Bet Now |
| RB Leipzig/Draw | 17.00 | Bet Now |
| Real Madrid/RB Leipzig | 34.00 | Bet Now |
UEFA Champions League odds correct as of 19/10/2026 and subject to change. Event scheduled to start at 22/10/2026 5:00am AEST.