After a frenetic festive calendar of 40 games in 14 days, it feels like an eternity since these sides have played in a League match.
With last weekend set aside for the FA Cup most of these clubs were able to enjoy a full week of rest to recover from the plethora of football.
One of the three top flight sides still involved in the midweek Carabao Cup semis, Tottenham, is also involved in the biggest match of the weekend against Manchester United at Wembley.
Read on for our previews, predictions and same game multis for all ten Premier League matches this weekend.
West Ham Vs Arsenal
Saturday 12 January, 11:30pm, London Stadium
A London derby to kick off Week 22 of the Premier League with Arsenal travelling to the Olympic Stadium.
This has been a very favourable fixture for the Gunners with 18 wins, four draws and just one loss in the last 12 seasons in all competitions.
While the away woes of the Wenger era have not been completely sold, Arsenal should be able to come away with all three points here.
Back Arsenal to Win @ $2.00
SGM: Arsenal to Win, Over 2.5 Goals, Alex Iwobi Anytime Goalscorer
Brighton and Hove Albion Vs Liverpool
Sunday 13 January, 2:00am, Amex Stadium
Invincible no longer, Liverpool are on a two game losing streak after dropping their last Premier League game to Manchester City and the FA Cup tie against Wolves.
On the plus side Liverpool has won all three Premier League meetings with Brighton with an aggregate score of 10-1 across those games.
With a four point lead on top of the table it is imperative that Liverpool holds serve in games like this if it wants to hold off the challenge of Manchester City.
Defensively Liverpool is still stout with a ridiculous 10 goals conceded all season so you can back them to keep a clean sheet with confidence.
Back Liverpool to Win to Nil @ $2.10
SGM: Liverpool to Win to Nil, Mo Salah First Goalscorer
Burnley Vs Fulham
Sunday 13 January, 2:00am, Turf Moor
Three straight wins and it looks like Burnley’s slow start might be behind them as the side tries to save itself from the current predicament.
Fulham is at least looking somewhat competitive under Claudio Ranieri although it has lost back to back games including a huge upset by League Two side Oldham in the FA Cup.
The Cottagers did in the first meeting between these sides in August for one of three victories this season.
Strikers on both teams will be eager to get a run in this game with the two leakiest defences in the competition.
This game could go either way, but there will be goals so for a betting play look for a high scoring clash.
Back Over 3.5 Goals @ $4.20
SGM: Burnley to Win, Over 3.5 Goals, Chris Wood Anytime Goalscorer
Cardiff Vs Huddersfield Town
Sunday 13 January, 2:00am, Cardiff City Stadium
Even though there is only eight points between these sides on the Premier League table, this is still one of the more straightforward games to pick this weekend.
Huddersfield’s last point came on November 25 and the Terriers were bundled out of the FA Cup by Bristol.
Cardiff has picked up points in two of its last three Premier League games but is also looking to bounce back from a rough loss in the FA Cup.
While you might not have a whole lot of confidence in the Bluebirds, you can back against the Terriers at over even money, take the value.
Back Cardiff to Win @ $2.20
SGM: Cardiff to Win, Under 3.5 Goals
Crystal Palace Vs Watford
Sunday 13 January, 2:00am, Selhurst Park
Palace has been in some good form over the past few weeks, picking up seven points from their Premier League commitments over Christmas and progressing in the FA Cup.
Watford has been pushing along as well with five points over Christmas and a Cup win as well.
This fixture favoured Palace as of late however the Hornets did win the reverse fixture in August, their first one in almost three years.
Watford has only lost once in its last six Premier League games and a draw looks like a good play here at $3.20
Back the Draw @ $3.20
SGM: Draw, Both Teams to Score
Leicester City Vs Southampton
Sunday 13 January, 2:00am, King Power Stadium
Leicester were looking good in the Premier League before an FA Cupset at the hands of Newport would have knocked the squad about.
There is a chance to bounce back this weekend though as they face a Southampton side that has only beaten them twice in the last five years.
Two of Southamptons three wins this season have come in the last four weeks but they find themselves as clear outsiders going to the King Power Stadium.
With Leicester hovering just under even money the value is on the Foxes to pick up a win against a side they are 11 places ahead of.
Back Leicester to Win @ $1.95
SGM: Leicester to Win, Over 2.5 Goals, Jamie Vardy Anytime Goalscorer
Chelsea Vs Newcastle
Sunday 13 January, 4:30am, Stamford Bridge
Winless in four, Newcastle would love to break out of that streak this weekend… unfortunately the fixture list has them facing Chelsea.
The Blues deployed a second string side in the Carabao Cup midweek so their big guns should be fit and firing for this one.
Chelsea are far from immune to an upset if the past few weeks are anything to go by, dropping points away to Wolves and at home to Leicester and Newcastle would love for that form to pop up here.
This looks like it will be a similar match to when these sides faced off at St James’ Park, earlier this season, just a bit colder.
Back Chelsea to Win and Both Teams to Score @ $3.25
SGM: Chelsea to Win, Over 2.5 Goals, Olivier Giroud Anytime Goalscorer
Everton Vs Bournemouth
Monday 14 January, 1:15am, Goodison Park
Four losses from Everton’s past five games has seen the Toffees drop from seventh to eleventh on the Premier League tables.
There is a good chance for them to bounce back when they host Bournemouth this weekend as they are on a similar form slump.
Four losses and a draw from the last six and eight losses from the last 11 games has seen the Cherries drop to 12th on the table and a defence leaking goals at an alarming rate is behind that drop.
Four at home to Liverpool, two away to Wolves, five away to Spurs, four away to Manchester United and a 3-3 draw at home to Watford suggests they will need to score plenty to keep up with Everton.
Back Over 3.5 Goals @ $2.60
SGM: Everton to Win, Over 3.5 Goals, Gylfi Sigurdsson Anytime Goalscorer
Tottenham Vs Manchester United
Monday 14 January, 3:30am, Wembley Stadium
The match of the round sees the resurgent Manchester United travel to Wembley, looking to atone for a 3-0 hammering from Spurs at Old Trafford.
A Tottenham win would see Spurs seal their first league double over United since 1989-1990 in the First Division.
It will be a step up from their last two Cup opponents with an 8-0 hammering of Tranmere in the FA Cup Third Round and a second string Chelsea side in the Carabao Cup Semi Final.
Spurs are the only Premier League side yet to record a draw this season but that run could end here as United face their biggest test under Solskjaer.
Back the Draw @ $3.60
SGM: Drawn Match, Both Teams to Score
Manchester City Vs Wolverhampton
Tuesday 15 January, 7:00am, Etihad Stadium
It’s a contest between the last two English sides to beat league leaders Liverpool, so it is imperative for City to avoid taking Wolves lightly.
Still trailing the Reds by four points, City can’t afford to drop points as they look to keep pace at the top of the table.
There was an upset draw at Molineux Stadium in August but the last five meetings have all gone the way of City.
Wolves can cause plenty of trouble here but City will be able to find a way to win.
Back Manchester City to Win to Nil @ $1.95
SGM: City to Win, Under 3.5 Goals, Leroy Sane Anytime Goalscorer
With the Third Round of the FA Cup on the horizon, Round 22 of the Premier League follows hot on the heels of Round 21.
Around 20 hours after the end of West Brom and Arsenal’s match, we are back underway with Brighton and Bournemouth which is where our preview for this round begins.
Brighton and Hove Albion Vs Bournemouth
Monday 1 January, 11:30pm, Amex Stadium
When these sides met twice in four days in September it was Brighton winning in both the League and Carabao Cup fixtures.
For the third round it turns to the home of the Seagulls where they have been resilient with three wins and five draws.
Bournemouth’s travels have seen them suffer a loss on six of ten occasions and this should follow that same pattern.
Back Brighton to Win @ $2.30
Burnley Vs Liverpool
Tuesday 2 January, 2:00am, Turf Moor
A potential debut for Liverpool’s record signing Virgil Van Dijk and when there is a player that costs in the area of A$129million you would be hoping he is able to hit the ground running.
Burnley won the last time these teams met at Turf Moor but there has been plenty of evolution in both sides since then.
Their first meeting this season yielded a 1-1 result at Anfield and I like another draw here as Burnley once again prove their mettle.
Back the Draw @ $4.25
Leicester Vs Huddersfield
Tuesday 2 January, 2:00am, King Power Stadium
A 1-1 draw was the result when these sides met in September and both desperately need a win at the moment.
Leicester are a solid proposition at home picking up 14 points so far while Huddersfield have just 8 points on the road.
It will not be easy here but you have to fancy Leicester to get the job done.
Back Leicester to Win @ $1.67
Stoke City Vs Newcastle United
Tuesday 2 January, 2:00am, Bet365 Stadium
A relegation six pointer for both sides as they look to give themselves some breathing room going forward.
Stoke’s home ground is not exactly the fortress is once was under Tony Pulis and Newcastle will want to really go for it here.
In the end both sides don’t really have the quality to get by here and instead look for a tight draw instead.
Back the Draw @ $3.20
Everton Vs Manchester United
Tuesday 2 January, 4:30am, Goodison Park
Everton love to play spoilers against Manchester United going back to when David Moyes was in charge of the Toffees.
Sam Allardyce will install a much more disciplined approach in Everton’s play compared to what was dished up at Old Trafford in September when United ran riot.
Getting any points out of this game might be a bit much for Everton but it should be a low scoring affair.
Back Manchester United to Win and Under 3.5 Goals @ $2.20
Southampton Vs Crystal Palace
Tuesday 2 January, 6:45am, St Mary’s Stadium,
Two in a row and four out of five for Southampton when they face Palace so there is plenty of confidence surrounding this game.
Palace have shown they are not the easybeats they were at the start of the season finding ways to run teams close.
Coming off their game with Manchester City it will be interesting to see how their confidence is faring.
Regardless of that result this has all the markings of a Southampton win.
Back Southampton to Win @ $1.91
West Ham Vs West Bromwich Albion
Tuesday 2 January, 6:45am, Olympic Stadium
The first of two games in the space of three days for West Ham they will be looking to take care of business against West Brom and turn their focus to the big game on the horizon.
With the Baggies one of the teams in striking distance of them on the ladder this game takes on even greater importance and West Ham should have the quality to get by.
Back West Ham to Win @ $1.91
Swansea Vs Tottenham
Tuesday 2 January, 6:45am, Liberty Stadium
Swansea helped contribute to Tottenham’s poor home form at the start of the season but it was a rare moment of joy this season as they sit at the wrong end of the Premier League table.
Historically Spurs have not feared travelling to the Liberty Stadium with plenty of fond memories there.
With Tottenham such heavy favourites and the potential for rotation here this game screams stay away.
Manchester City Vs Watford
Tuesday 2 January, 7:00am, Etihad Stadium
City love playing Watford with seven straight wins during the CFG era.
The last two games have been huge wins with 11 goals scored and none conceded and there is nothing to suggest this game will be any different.
In a surprise to absolutely nobody, City are huge favourites here, so the value comes in at how much you expect them to win by.
The only point to consider is how much City opt to rotate their side through but even a second string side is very good with the money they have invested in it.
Back City to Win -2 Goals @ $1.91
Arsenal Vs Chelsea
Thursday 4 January, 6:45am, Emirates Stadium
Aside from their Anfield capitulation in August, Arsenal have found a way to stay competitive in their matches against top opponents this year, particularly at home.
A 2-0 win against Tottenham, battering down the door against Manchester United only to be denied by David De Gea heroics and a fighting 3-3 draw against Liverpool suggest that they should be competitive in this game and not get blown out.
The maturity they displayed to escape with a 0-0 draw at Stamford Bridge earlier this year show that they can hold out here and this looks like a match they should find a way to get out of this with a confidence boosting win.
Back Arsenal to Win @ $2.38
Tottenham Vs West Ham United
Friday 5 January, 6:45am, Wembley Stadium
Another London Derby to close out a massive fortnight in the Premier League and it may also be known as the new stadium derby.
As has been mentioned once or twice this year, Spurs are renting out Wembley while White Heart Lane is refurbished and this is always a game both sets of fans look forward to.
If Harry Kane is able to back up the form he showed in 2017 then you fancy his chances to get 2018 off on a good note here.
The safe play here is to back Kane to score at anytime and that is the recommendation however a brace is certainly not out of the question.
Back Harry Kane to Score First @ $3
The 2016/2017 English Premier League season continues this weekend and there are a number of very interesting games.
The highlight will be at Etihad Stadium when Manchester City host Tottenham Hotspur in what could be a vital clash, while Southampton will face defending champions Leicester City in a another intriguing fixture.
There will be plenty of betting interest in every single clash this weekend and you can find all the best betting plays below.
Liverpool Vs Swansea City
Saturday 21 January, 11:30pm, Anfield
Liverpool took a point from their clash with Manchester United last weekend and they have not lost a game in the English Premier League for over a month.
It is no surprise that Liverpool will go into this clash as clear favourites and they have now improved their record as home favourites to 10-6-0 over the past 12 months.
Swansea City were no match for Arsenal last weekend and they have now lost five of their past six games.
The Welsh-based side have won four of their past 18 games as away underdogs for a massive profit, but it is very tough to trust them from a betting standpoint in this clash.
The market looks to have got this clash just about right and I am happy to stay out.
Bournemouth Vs Watford
Sunday 22 January, 1:00am, Goldsands Stadium
Bournemouth have won just one of their past five games, but they will still go into this clash with Watford as clear favourites.
Bournemouth have won four of their past eight games as home favourites for a narrow profit, but they have drawn all three of their previous meetings with Watford since they made the leap to the English Premier League.
Watford played out a scoreless draw with Middlesbrough last weekend and they have not won a game for over a month.
They have won just four of their past 17 games as away underdogs for a clear loss and it is tough to see them taking three points from this clash.
The stalemate is clearly the value option in this clash and the $3.50 is one of the best value plays of the weekend.
Back The Draw @ $3.50
Crystal Palace Vs Everton
Sunday 22 January, 1:00am, Selhurst Park
Everton are coming off their best performance of the season and will go into this clash as favourites.
Everton were nothing short of outstanding against Manchester City and a repeat of that performance would be more than good enough to beat Crystal Palace, but consistency has been somewhat of an issue.
They have won four of their past nine games as away favourites for a narrow loss and their record away from home is generally fairly poor.
Crystal Palace have lost five of their past six games and have really struggled in front of goal in recent weeks.
They have now won only one of their past eight games as home underdogs for a big loss and they have been very tough to trust from a betting perspective this season.
Everton are well over the odds at their current price and should be able to get the job done comfortably.
Back Everton To Win @ $2.30
Middlesbrough Vs West Ham United
Sunday 22 January, 1:00am, Riverside Stadium
Middlesbrough have not won for over a month, but they will still go into this clash with West Ham as clear favourites.
Middlesbrough have played out scoreless draws in their past two clashes with Leicester City and Watford, with their record as home favourites now a non-profitable 3-2-2.
West Ham have had plenty of off-field problems in the past week – with star Dimitri Payet refusing to train with the team – but they were ruthless against Crystal Palace last weekend.
They have only won three of their past 14 games as away underdogs, but they have drawn five of these games for a profit.
There really is not a great deal between these two teams and the draw is definite value at the $3.
Back The Draw @ $3
Stoke City Vs Manchester United
Sunday 22 January, 1:00am, Brittania Stadium
Stoke City have won two games on the trot, but it is Manchester United that will go into this clash as clear favourites.
Manchester United had their winning run ended by Liverpool last weekend and they have now won seven of their past 12 games as away favourites to basically break even for punters.
There has been plenty to like about the way that Stoke City have played in the past couple of weeks, but this is obviously a much tougher challenge.
Stoke City have only won one of their past eight games as home underdogs for a clear loss, but they have drawn three games in this scenario.
This is another game that the market looks to have got just about right and I am happy to stay out from a betting standpoint.
West Bromwich Albion Vs Sunderland
Sunday 22 January, 1:00am, The Hawthorns
West Bromwich Albion were at the receiving end of a heavy defeat at the hands of Tottenham last weekend and they will still go into this clash as clear favourites.
The Baggies have won their two fixtures before that, but they have still won only four of their past ten games as home favourites for a loss.
Sunderland made it three losses from their past four games when they went down to Stoke City and wins have been few and far between this season.
They have won only two of their past 16 games as away underdogs for a clear loss, but they have been able to draw five games in this scenario.
It is tough to get West Brom as short as their current quote and the $3.60 available for the draw is genuine value.
Back The Draw @ $3.60
Manchester City Vs Tottenham Hotspur
Sunday 22 January, 3:30am, Etihad Stadium
This is easily the biggest game of the weekend and is a crucial clash for both sides.
Manchester City suffered a heavy defeat at the hands of Everton last weekend, but they will still go into this clash as clear favourites.
Pep Guardiola’s men have won only nine of their past 17 games as home favourites for a clear loss and they have lost their past three games to Tottenham.
Tottenham made it six wins on the trot with their emphatic victory over West Bromwich Albion and they have been in outstanding form in recent weeks.
They have only won one of their past six games as away underdogs for a loss, but they have drawn three of their games in this scenario.
Backing the draw in games involving these teams has proven to be a profitable play all season long and the $3.30 for the stalemate is over the odds.
Back The Draw @ $3.30
Southampton Vs Leicester City
Sunday 22 January, 10:00pm, St Mary's Stadium
It is Southampton that will start this clash with Leicester City as clear favourites – despite the fact that they have lost four games on the trot.
Southampton’s defence has had big issues in recent weeks, but they have still proven to be a winning betting proposition and have won eight of their past 12 games as home favourites.
Leicester City were no match for Chelsea last weekend and they have really struggled for any sort of consistency in the English Premier League this season.
The defending champions have won only one of their past ten games as away underdogs for a clear loss and they have been tough to trust from a betting perspective this season.
I am willing to give Southampton one more chance and they should be able to return to winning form this weekend.
Back Southampton To Win @ $1.91
Arsenal Vs Burnley
Monday 23 January, 12:15am, Emirates Stadium
Arsenal are one of the shortest-priced favourites of the weekend in the English Premier League.
Arsenal returned to winning form with an emphatic 4-0 victory over Swansea City last weekend and in their three previous meetings with Burnley they have won to nil.
They have improved their record as home favourites to 12-4-2, but they have still been a losing betting proposition in this scenario.
Burnley beat Southampton last weekend, but winning away from home has proven to be a big issue thus far this season.
Sean Dyche’s men have lost eight of their nine games away from home this season and this does not look like changing this weekend.
Back Arsenal To Win To Nil @ $1.85
Chelsea Vs Hull City
Monday 23 January, 2:30am, Stamford Bridge
Chelsea sit seven points clear on top of the English Premier League ladder and they are the shortest-priced favourites of the weekend.
They returned to winning form with a comfortable victory over Leicester City following their surprise loss at the hands of Tottenham and outside of that defeat they have been almost unbeatable in the English Premier League this season.
Hull City finally returned to winning form against Bournemouth last weekend, but they obviously face a much tougher challenge against Chelsea.
Hull have won just one of their past 10 games as away underdogs this season for a clear loss and it would be a big surprise if they were able to improve that in this clash.
Chelsea should obviously get the job done, but there really is not a great deal of value at the current price.