This is the time for squad depth to come to the fore as all 20 Premier League sides face their third game in the space of a week.
There are no signs of football fatigue just yet though, as the big games keep coming this weekend.
It is hard to look past Chelsea hosting Manchester City as the biggest contest of the weekend, but all 10 games carry a certain level of intrigue from a punting perspective.
Read on for our previews, predictions and same game multis from every Premier League fixture coming up.
Bournemouth Vs Liverpool
Saturday 8 December, 11:30pm, Vitality Stadium
Bournemouth will be eager to back up from their first win in over a month when they host the rampant Reds at the Vitality Stadium.
Unfortunately for them, the market for this game does not paint a pretty picture for their chances here and neither does their recent history.
They lost both games against Liverpool convincingly last season, 4-0 at home and 3-0 when they travelled to Anfield.
With the way Liverpool looked in the second half of their win over Burnley midweek, this game only appears to have one clear result and that is a convincing Liverpool win.
Back Liverpool to Win Both Halves @ $4.60
SGM: Liverpool to Win, Liverpool to Score 2+ Goals, Mo Salah Anytime Goalscorer
Arsenal Vs Huddersfield Town
Sunday 9 December, 2:00am, Emirates Stadium
After a couple of tough games against Tottenham and Manchester United, Arsenal won’t want to overlook a tough test against relegation battlers Huddersfield.
Every point is critical for the Terriers and they will be hoping to do better than their last trip to the Emirates where they were crushed 5-0 last season.
The Gunners have not lost at home since the opening day of the Premier League season and enter this game as heavy favourites.
After their midweek draw at Old Trafford they will be eager to take all three points with a convincing performance here.
Back Arsenal to Win to Nil @ $2.10
SGM: Arsenal to Win, Pierre-Emerick Aubameyang First Goalscorer
Burnley Vs Brighton and Hove Albion
Sunday 9 December, 2:00am, Turf Moor
After another loss, this time against Liverpool, this season goes from bad to worse for Burnley as they prepare to host a Brighton side unbeaten in three.
They were very impressive in their last up win over Crystal Palace, especially after being reduced to 10 men in the first half.
There were no goals in either meeting between these sides last season and it would not be at all surprising if they can’t be split again.
Back the Draw @ $3.00
SGM: Drawn Match, Both Teams to Score, Sam Vokes Anytime Goalscorer
Cardiff Vs Southampton
Sunday 9 December, 2:00am, Cardiff City Stadium
There were more blues for Cardiff as they could not turn a promising start into points against West Ham during the week.
Southampton are one of the few sides doing worse than Cardiff this season with an 11-game winless run, most recently extended with a 3-1 loss at Tottenham during the week.
This will be the first meeting in four and a half years for these sides and both will see this as a big three points to pick up in the context of the relegation battle.
This game has the makings of a low scoring affair where one goal might just be enough to win it, although a scoreless draw would not surprise either.
Back Both Teams to Score (No) @ $1.87
SGM: Drawn Match, Under 2.5 Goals
Manchester United Vs Fulham
Sunday 9 December, 2:00am, Old Trafford
It wasn’t pretty but Fulham’s five match losing run ended with a point at home to Leicester as they now travel to Old Trafford.
On their last trip there in 2014, they did pick up a point on a late equaliser but their last outright win at this venue came in 2003.
As you would expect this fixture has been dominated by United and even with the hosts in their current malaise.
Three straight draws and at least two of those games they should have been able to find a way to win, but something is not right with this side.
Despite the struggles Mourinho has finding a balance in his team, they still should be able to fluke their way into a couple of goals even if they turn in a wretched performance, a clean sheet probably won’t happen, but a win will.
Back Manchester United to Win and Both Teams to Score @ $2.80
SGM: United Win, Jesse Lingard Anytime Goalscorer, Aboubakar Kamara Anytime Goalscorer
West Ham Vs Crystal Palace
Sunday 9 December, 2:00am, London Stadium
It was hard not to be impressed with West Ham’s strong finish during the week as they wound up with a comfortable 3-1 win over Cardiff.
Palace endured a rough evening at Brighton going down 3-1 despite enjoying a man advantage for over an hour.
Consistency has been a big problem for West Ham as of late, with their midweek victory the only time they had won back to back Premier League games since January 2017.
With that in mind, even though they are still the better side compared to Palace, it would not be at all surprising to see them stumble to a draw here, especially when both meetings last season ended in a draw.
Back the Draw @ $3.25
SGM: Drawn Match, Both Teams to Score, Lucas Perez Anytime Goalscorer
Chelsea Vs Manchester City
Sunday 9 December, 4:30am, Stamford Bridge
The big games just keep coming and Chelsea are next in line as they try to hand Manchester City their first Premier League defeat of the season.
After 15 games, the defending champions have won 13 and drawn twice so far and should enter this game full of confidence having won both League meetings between the sides last year.
Chelsea were flat and out of sorts against Wolves during the week and perhaps were caught with one eye on this fixture, but the fact they have won just once in their last four matches and this is one of their toughest tests of the season.
Even as a clear road favourite, City are the play here, they are just too good and should find a way to hold off Chelsea.
Back Manchester City to Win @ $1.87
SGM: City to Win, Both Teams to Score, Sergio Aguero Anytime Goalscorer
Leicester City Vs Tottenham
Sunday 9 December, 6:45am, King Power Stadium
Tottenham’s busy schedule continues with a trip to Leicester, ahead of a massive Champions League encounter however Mauricio Pochettino cannot afford to rotate his squad too much with every point critical for his side right now.
These sides split the fixtures last season with both sides taking all three points at home and both enter this contest in decent form.
Leicester are unbeaten in their last six, by way of battling for draws and they are at a good price to repeat that effort here, although Tottenham winning four of their last five is very tough to back against.
Spurs did have trouble with Southampton early on and Leicester could get on top of them early, forcing them to battle back into the match.
Back the Draw @ $3.50
SGM: Draw, Harry Kane Anytime Goalscorer, Jamie Vardy Anytime Goalscorer
Newcastle Vs Wolverhampton
Monday 10 December, 3:00am, St James’ Park
After a season apart, Newcastle and Wolverhampton are reunited once again and both enter this game with relatively high levels of confidence after their midweek performances.
Newcastle battled for a draw away to Everton which has been a tough place for visiting teams and Wolves pulled off one of the best upsets of the season topping Chelsea.
With Newcastle picking up 10 points from their last five games they have been able to give themselves some breathing room away from the bottom of the table.
That being said Wolves have travelled well, picking up points in four of their seven road games and are at good value to continue their winning form.
Back Wolves to Win @ $2.63
SGM: Wolves to Win, Over 2.5 Goals, Raul Jimenez Anytime Goalscorer
Everton Vs Watford
Tuesday 11 December, 7:00am, Goodison Park
This past week has been rough for Everton, starting off with a Merseyside Derby defeat on basically the last kick of the game before dropping points at home to Newcastle.
To close out Round 16 of the Premier League, they host a Watford side they have had mixed fortunes against over the past three seasons.
With two wins each and two draws, this is the very definition of an even fixture, however home ground advantage has been pivotal in these results.
Everton have won the last two meetings at Goodison Park and enter this game as favourites and should be able to take care of business as they look to put the last two games behind them.
Back Everton to Win @ $1.75
SGM: Everton to Win, Over 1.5 Goals, Theo Walcott Anytime Goalscorer
A couple of massive derbies headline EPL Round 16 with bragging rights on Merseyside and Manchester up for grabs.
Everton are spiraling and will hope that Sam Allardyce’s familiarity with the Premier League having managed so many other clubs will come in handy when they go across the park to visit Liverpool.
Manchester United would love nothing more than to end their neighbours unbeaten start to the year.
West Ham United Vs Chelsea
Saturday December 9, 11:30pm, Olympic Stadium
Without a win since October 1, West Ham are going to have a hard time breaking that streak when Chelsea visit the Olympic Stadium.
The Blues last loss came on October 15th and they have dropped points once since that day against Liverpool.
Eden Hazard is starting to look like a player of the season candidate once more and his double against Newcastle is cause for concern for all opponents going forward.
These games sometimes have the makings of a major upset, but the top five sides as a whole are on a great run of form against the rest of the league and that should continue here.
Back Chelsea to Win to Nil @ $2.45
Burnley Vs Watford
Sunday December 10, 2:00am, Turf Moor
The Premier League’s “best of the rest” face off with seventh and eighth placed sides looking to continue their impressive starts.
Burnley have lost two of their last three outings against Arsenal and Leicester but they have been far from disgraced in either showing.
Watford showed they can compete with the big boys after a 1-1 draw with Tottenham last weekend.
Neither side will want to give up any ground here and as a result of that they both drop points with a draw.
Back the Draw @ $3.10
Crystal Palace Vs Bournemouth
Sunday December 10, 2:00am, Selhurst Park
Bournemouth will not be fazed by their trip to Selhurst Park, they are yet to lose at this venue in the Premier League.
Of course that span only covers two matches in the top flight with a 2-1 Bournemouth win and a 1-1 draw.
A lot has passed in that time and Bournemouth have not won since the November international break.
Palace are undefeated in their last four and I like them to win at home here and take another step forward.
Back Palace to Win @ $2.00
Huddersfield Town Vs Brighton And Hove Albion
Sunday December 10, 2:00am, John Smith’s Stadium
About as close to an Aussie derby as we will get in the Premier League this season with Aaron Mooy and Mat Ryan set to start for their respective clubs.
These two sides are almost inseparable having been in the same division for the past twelve seasons. Life in the Championship was slightly more favourable to Brighton with four wins and five draws in their ten meetings.
As of late Huddersfield’s solid start has come undone, losing five of six and being on the receiving end of some big scorelines.
Brighton will be looking to get bounce back from an embarrassing 5-1 loss to Liverpool and both sides will find a way to cancel each other out.
Back the Draw @ $2.90
Swansea City Vs West Bromwich Albion
Sunday December 10, 2:00am, Liberty Stadium
Anchored to the bottom of the Premier League table, Swansea will view this as a great chance to get their third win of the campaign.
Fellow strugglers West Brom come to town and while a win for the home side will not be enough to get them off the bottom of the table, it would at least close the gap to the safety zone.
Swansea have won the last three matches between these sides at the Liberty Stadium.
West Brom are on a run of three straight draws and are winless since the second game of the season.
Back Swansea to Win @ $2.60
Tottenham Hotspur Vs Stoke City
Sunday December 10, 2:00am, Wembley
Working in Tottenham’s favour is the fact they will not have played the most competitive Champions League match midweek.
They will be relatively fresh for a league match that they desperately need to win.
Their stars are not getting the job done with just two points in their last four matches, this form slide needs to be arrested quickly.
With three straight wins against Stoke this should be the right time to get themselves back on track.
Back Tottenham to Win & Under 2.5 Goals @ $4.00
Newcastle United Vs Leicester City
Sunday December 10, 4:30am, St James’ Park
Much like last season, Leicester have experienced a resurgence after their manager has been sacked.
They have been able to grind out one goal wins in their last two games and have a great chance to do that once more when they visit a Newcastle side that cannot buy a win.
Leicester’s away form has been encouraging too with two losses, both coming in August to Manchester United and Arsenal.
Since then they are unbeaten in five and should stretch that to six here.
Back Leicester to Win @ $2.75
Southampton Vs Arsenal
Sunday December 10, 11:00pm, St Mary’s Stadium
Until last season, league fixtures against Southampton were a cause of great frustration for Arsenal.
At one point it was three straight games where the Saints had taken points of the Gunners.
Last year though that streak snapped and Arsenal completed their first sweep in the league since their Invincibles campaign.
After a frustrating loss at home to Manchester United it is a great opportunity to bounce back and I like their odds to do just that.
Back Arsenal to Win @ 1.91
Liverpool Vs Everton
Monday December 11, 1:15am, Anfield
Two sides whose grounds are separated by Stanley Park get together for the 280th time.
They say you can throw out recent form in a derby which is great for an Everton side that have struggled this season.
Their record in this fixture is not much better with their last win coming in October 2010 while Liverpool are on a run of three straight wins.
It might not be overly pretty, as derbies rarely are, but Liverpool will find a way to win and I like Salah to find the key goal.
Back Salah to score and Liverpool to Win @ $2.15
Manchester United Vs Manchester City
Monday December 11, 3:30am, Old Trafford
While this game will not mathematically end the title race, a win for City would put them eleven points clear at the top of the table and in their current form that is a big lead to have.
So no pressure on Manchester United to perform in this game.
They are fresh off a smash and grab win at Arsenal, who will go into this game without Paul Pogba due to suspension.
As much as they may be tempted to try and replicate that game plan here, they cannot afford to give the likes of Sergio Aguero that many chances.
Back the Draw @ $3.40
It is the first midweek round of the 2016/2017 English Premier League season as the depth and fitness of the 20 teams in the competition will be tested.
The pick of the games on Thursday morning is the intriguing clash between Everton and Arsenal at Goodison Park, while Crystal Palace will take some confidence into their battle with Manchester United at Selhurst Park.
There is nothing better than midweek EPL action and you can find the best betting plays for all ten matches below.
Bournemouth Vs Leicester City
Wednesday 14 December, 5:45am, Goldsands Stadium
Bournemouth have won just four of their past 10 games as home favourites for a clear loss, while Leicester City have taken at least a point from six of their past 11 games as away underdogs.
Back Leicester City To Win @ $2.90
Sunderland Vs Chelsea
Wednesday 14 December, 5:45am, Stadium Of Light
Chelsea have won nine of their past 13 games as away favourites for a clear profit, but Sunderland are 3-2-5 as home underdogs.
West Ham United Vs Burnley
Wednesday 14 December, 5:45am, Olympic Stadium
West Ham have won lost only two of their past ten games as home favourites and Burnley have lost five of their past six games as away underdogs.
Back West Ham To Win @ $1.67
West Bromwich Albion Vs Swansea City
Wednesday 14 December, 6:00am, The Hawthorns
West Bromwich Albion have won only three of their past nine games as home favourites, while Swansea City have been highly profitable as away underdogs.
Back Swansea City To Win @ $3.80
Middlesbrough Vs Liverpool
Thursday 15 December, 5:45am, Riverside Stadium
Middlesbrough have lost both their games as home underdogs this season, but Liverpool are an unconvincing 7-1-7 as away favourites.
Everton Vs Arsenal
Thursday 15 December, 5:45am, Goodison Park
Everton have been able to take a point from three of their past four games as home underdogs, while Arsenal have drawn four of their past 13 games as away favourites.
Back The Draw @ $3.60
Crystal Palace Vs Manchester United
Thursday 15 December, 6:00am, Selhurst Park
Crystal Palace have won only one of their past seven games as home underdogs, while Manchester United have won four of their past 11 games as away favourites.
Manchester City Vs Watford
Thursday 15 December, 6:00am, Etihad Stadium
The over has saluted in 25 of the past 36 games played by Manchester City, while it is 20-16 in games involving Watford.
Back Over 3.6 Goals @ $4
Stoke City Vs Southampton
Thursday 15 December, 6:00am, Britannia Stadium
Southampton have won only three of their past nine games as away favourites, but Stoke City don’t have a much better record as home underdogs.
Tottenham Hotspur Vs Hull City
Thursday 15 December, 6:00am, White Hart Lane
Tottenham Hotspur have won 10 of their past 16 games as home favourites and Hull City have won just one of their past seven fixtures as away underdogs.
Back Tottenham To Win To Nil @ $2